Daniel R. Krewski
Professor of Biostatistics, Faculty of Medicine,
University of Ottawa
Board of Directors, LRSP
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Dr. Krewski is currently Professor of Medicine and Professor of Epidemiology and Community Medicine at the University of Ottawa, where he is involved in a number of activities in population health risk assessment within the new Institute of Population Health. Dr. Krewski has also served as Adjunct Research Professor of Statistics in the Department of Mathematics and Statistics at Carleton University since 1984.
Prior to joining the Faculty of Medicine at the University of Ottawa in 1998, Dr. Krewski was Director, Risk Management in the Health Protection Branch of Health Canada. Dr. Krewski joined the Health Protection Branch of Health Canada in 1972, and has extensive experience with a wide variety of health protection issues, particularly in relation to food safety and environmental health. While with Health Canada, he also served as Director of the Bureau of Chemical Hazards and as Chief of the Biostatistics Division in the Environmental Health Directorate.
Dr. Krewski obtained his Ph.D. in statistics from Carleton University and subsequently completed an M.H.A. at the University of Ottawa. His professional interests include epidemiology, biostatistics, risk assessment, and risk management. Dr. Krewski is a Fellow of the American Statistical Association and the Society for Risk Analysis. Dr. Krewski has contributed to over 300 publications in the scientific and technical literature, and is author or editor of five books. He is currently an Associate Editor of Risk Analysis, Risk Abstracts, and the Journal of Epidemiology and Biostatistics.
Dr. Krewski has been a member of a number of expert panels on health risk assessment, including committees established by the American Health Foundation, the International Life Sciences Institute, the the International Programme on Chemical Safety. From 1992 to 1996, Dr. Krewski served as the Canadian representative on the Scientific Council of the International Agency for Research on Cancer. He currently serves as a member of the Board on Environmental Studies and Toxicology within the U.S. National Academy of Sciences, and has recently been appointed Chair of the Royal Society of Canada's Expert Panel on the Potential Health Risks of Exposure to Radiofrequency Fields from Wireless Telecommunications Devices.
Crump, K.S., Krewski, D. and Wang, Y. (1998). Estimates of the number of liver carcinogens in bioassays conducted by the National Toxicology Program. Risk Analysis18, 299-308. Applies the meta-analytic techniques developed by Bickis et al. (1996) to show that there are appreciably more liver carcinogens among the 400 chemicals tested to date than have been identified by the U.S. National Toxicology Program.
Ashmore, J.P., Krewski, D., Zielinski, J.M., Jiang, H., Semenciw, R., and Letourneau, E.G. (1998). First analysis of occupational radiation mortality based on the National Dose Registry of Canada.American Journal of Epidemiology. In press. Conducted analysis of excess cancer risks among largest cohort of people (over 500,000 Canadians) subjected to occupational radiation exposures.
Bickis, M., Bleuer, S. and Krewski, D. (1996). Estimation of the proportion of positives in a sequence of screening experiments. Canadian Journal of Statistics 24, 1-15. Developed new meta-analytic methods for combining information from multiple studies. (Awarded best paper of 1996 by the Statistical Society of Canada.)
Fung, K.Y., Krewski, D. and Smythe, R.T. (1996). A comparison of tests for trend with historical controls in carcinogen bioassay. Canadian Journal of Statistics 24, 431-454. Identified most suitable tests for trend in count data utilizing historical controls in carcinogenicity experiments based on analytical, simulation, and empirical comparisons of a large number of tests proposed by different authors.
Krewski, D., Wang, Y., Bartlett, S. and Krishnan, K. (1995). Uncertainty, variability, and sensitivity analysis in physiological pharmacokinetic models. Journal of Biopharmaceutical Statistics 5, 245-271. Developed new framework for analysis of uncertainty and variability, as applied to complex physiologic pharmacokinetic models with 20-40 parameters.
Ashmore, J.P., Krewski, D., Zielinski, J.M., Jiang, H., Semenciw, R., and Letourneau, E.G. (1998). First analysis of occupational radiation mortality based on the National Dose Registry of Canada.American Journal of Epidemiology.In press (September 15 issue).
Bangsi, D., Ghadirian, P., Ducic, S., Ciccocioppo, S., McMullen, E. and Krewski, D. (1998). Dental amalgam and multiple sclerosis: a case control study in Montreal, Canada. International Journal of Epidemiology 27, 667-671.
Cakmak, S., Burnett, R. and Krewski, D. (1998). Adjusting for temporal variation in the analysis of parallel time series of health and environmental variables. Risk Analysis. In press.
Crump, K.S. and Krewski, D. (1998). Estimation of the number of studies with positive trends when studies with negative trends are present. Canadian Journal of Statistics 26. In press.
Crump, K.S., Krewski, D. and Vanlandingham, C. (1998). Estimates of the proportion of chemicals that were carcinogenic, anti-carcinogenic or either in bioassays conducted by the National Toxicology Program. Environmental Health Perspectives. To appear.
Crump, K.S., Krewski, D. and Wang, Y. (1998). Estimates of the number of liver carcinogens in bioassays conducted by the National Toxicology Program. Risk Analysis18, 299-308.
Dewanji, A., Goddard, M.J., Krewski, D. and Moolgavkar, S.H. (1998). Two stage model for carcinogenesis: analysis of longitudinal data on the number and size of premalignant clones.Mathematical Biosciences. To appear.
Fung, K.Y., Douglas, G.R. and Krewski, D. (1998). Statistical analysis of lacZ mutant frequency data from Muta Mouse mutagenicity assays. Mutagenesis 13, 249-255.
Fung, K. and Krewski, D. (1998). Evaluation of quasi-likelihood, regression calibration, and SIMEX methods in logistic regression when one of the predictors is subject to additive measurement error.Journal of Epidemiology and Biostatistics. To appear.
Fung, K.Y., Lin, X., and Krewski, D. (1998). The use of generalized linear mixed models in analyzing mutant frequency data from the transgenic mouse assay. Environmental and Molecular Mutagenesis 31, 48-54.
Fung, K.Y., Marro, L., and Krewski, D. (1998). A comparison of methods for estimating the benchmark dose based on overdispersed data from developmental toxicity studies. Risk Analysis 18, 329-342.
Gaylor, D., Ryan, L., Krewski, D. and Zhu, Y. (1998). Procedures for calculating benchmark doses for health risk assessment.Regulatory Toxicology and Pharmacology. To appear.
Gerin, M., Siemiatycki, J., Desy, M. and Krewski, D. (1998). Associations between several sites of cancer and occupational exposure to benzene, toluene, xylene and styrene: results of a case control study in Montreal. American Journal of Industrial Medicine34, 144-156.
Rai, S.N. and Krewski, D. (1998). Analysis of uncertainty and variability in multiplicative risk models. Risk Analysis 18, 37-45.
Ashmore, J.P., Krewski, D. and Zielinski, J.M. (1997). Protocol for a cohort mortality study of occupational radiation exposure based on the National Dose Registry of Canada. European Journal of Cancer 33 (Suppl. 3), S10-S21.
Band, P., Nhu, L.D., Fang, R., Threfall, W.J., Astrakianakis, G., Anderson, J.T.L., Keefe, A. and Krewski, D. (1997). Cohort mortality study of pulp and paper workers in British Columbia, Canada. American Journal of Epidemiology 146, 186-194.
Boyle, P., Krewski, D., Ashmore, P., Cardis, E. and Zielinski, J.M. (1997). Radiation epidemiology and national dose registers. European Journal of Cancer 33 (Suppl. 3), S1-S2.
Burnett, R.T., Brook, J.R., Yung, W., Dales, R.E. and Krewski, D. (1997). Association between ozone and hospitalization for respiratory diseases in 16 Canadian cities. Environmental Research 72, 24-31.
Burnett, R.T., Dales, R.E., Brook, J.R., Raizenne, M.E. and Krewski, D. (1997). Association between ambient carbon monoxide levels and hospitalizations for congestive heart failure in the elderly in 10 Canadian cities.Epidemiology 8,162-167.
Fung, K.Y., Krewski, D. Zhu, Y., Shephard, S. and Lutz, W.K. (1997). Statistical analysis of the lacI transgenic mouse assay. Mutation Research 374, 21-40.
Morrison, H, Krewski, D., Bartlett, S. and Riedel, D. (1997). Cancer risks of occupational exposure to agricultural chemicals in Canadian farm operators. Journal of Epidemiology and Biostatistics 2, 102-120.
Pelekis, M., Krewski, D. and Krishnan, K. (1997). Physiologically based algebraic expressions for predicting steady-state toxicokinetics of inhaled vapours. Toxicology Methods 7, 207-228.
Zielinski, J.M., Krewski, D., Ashmore, P. and Cardis, E. (1997). The use of national registers of radiation exposure in occupational radiation risk assessment. European Journal of Cancer 33 (Suppl. 3), S3-S6.
Bartlett, S., Richardson, G.M., Krewski, D., Rai, S.N. and Fyfe, M. (1996). Characterizing uncertainty in risk assessment - conclusions drawn from a workshop. Human and Ecological Risk Assessment. 2, 221-231.
Bickis, M., Bleuer, S. and Krewski, D. (1996). Estimation of the proportion of positives in a sequence of screening experiments. Canadian Journal of Statistics 24, 1-15.
Fung, K.Y., Krewski, D. and Smythe, R.T. (1996). A comparison of tests for trend with historical controls in carcinogen bioassay. Canadian Journal of Statistics 24, 431-454.
International Expert Panel on Carcinogen Risk Assessment. The Use of Mechanistic Data in the Risk Assessments of Ten Chemicals: An Introduction to Chemical Specific Reviews. (1996). Pharmacology and Therapeutics 71, 1-5.
Rai, S.N., Krewski, D. and Bartlett, S. (1996). A general framework for the analysis of uncertainty and variability in risk assessment. Human and Ecological Risk Assessment2, 972-989.
Zielinski, J.M., Krewski, D., Goddard, M.J. and Wang, Y. (1996). Empirical and biologically based models for cancer risk assessment. Drug Metabolism Reviews 28, 53-75.
Burnett, R.T., Ross, W.H. and Krewski, D. (1995). Nonlinear random effects regression models. Environmetrics 6, 85-89.
Burnett, R.T., Dales, R., Krewski, D., Vincent, R., Dann, R. and Brook, J.R. (1995). Associations between ambient particulate sulfate and admissions to Ontario hospitals for cardiac and respiratory diseases. American Journal of Epidemiology 142, 15-22.
Denes, J. and Krewski, D. (1995). An exact representation of the generating function for the Moolgavkar-Venzon-Knudson two-stage model of carcinogenesis with stochastic stem cell growth. Mathematical Biosciences 131, 185-204.
Goddard, M.J. and Krewski, D. (1995). The future of mechanistic research in risk assessment: Where are we going and can we get there from here? Toxicology 102, 53-70, 1995.
Goddard, M.J., Krewski, D. and Morrison, H. (1995). Environmental epidemiology in Canada. Environmental Health Reviews 39, 72-84.
Goddard, M.J., Murdoch, D. J. and Krewski, D. (1995). Temporal aspects of risk characterization. Inhalation Toxicology 7, 1005-1018.
Hrudey, S.E. and Krewski, D., (1995). Is there a safe level of exposure to a carcinogen? Environmental Science and Technology 29, 370A-375A.
Krewski, D., Smythe, R.T., Dewanji, A. and Szyszkowicz, M. (1995). Bootstrapping an empirical Bayes estimator of the distribution of historical controls in carcinogen bioassay. Journal of Statistical Planning and Inference 43, 215-228.
Krewski, D., Wang, Y., Bartlett, S. and Krishnan, K. (1995). Uncertainty, variability, and sensitivity analysis in physiologic pharmacokinetic models. Journal of Biopharmaceutical Statistics 5, 245-271.
Krewski, D., and Zhu, Y. (1995). A simple data transformation for estimating benchmark doses in developmental toxicity experiments. Risk Analysis 15, 29-39.
Krewski, D., Slovic, P., Bartlett, S., Flynn, J. and Mertz, C.K. (1995). Health risk perception in Canada I: rating hazards, sources of information, and responsibility for risk protection. Human and Ecological Risk Assessment 1, 117-132.
Krewski, D., Slovic, P., Bartlett, S., Flynn, J. and Mertz, C.K. (1995). Health risk perception in Canada II: worldviews, attitudes, and opinions. Human and Ecological Risk Assessment 1, 53-70.
Krewski, D., Wang, Y., Bartlett, S. and Krishnan, K. (1995). Uncertainty, variability, and sensitivity analysis in physiologic pharmacokinetic models. Journal of Biopharmaceutical Statistics 5, 245-271.
Nadon, L., Siemiatycki, J., Dewar, R., Krewski, D. and Gerin, M. (1995). Risk of cancer due to occupational exposure to polycyclic aromatic hydrocarbons. American Journal of Industrial Medicine 28, 303-324.
Siemiatycki, J., Krewski, D., Franco, E. and Kaiserman, M. (1995). Associations between cigarette smoking and each of 21 types of cancer: results of a multi site case control study in Montreal. International Journal of Epidemiology 24, 504-514.
Slovic, P., Malmfors, T., Krewski, D., Mertz, C.K., Neil, N. and Bartlett, S. (1995). Intuitive toxicology II: expert and lay judgements of chemical risks in Canada. Risk Analysis 15, 661-675.
Burnett, R., Bartlett, S. and Krewski, D., Raad-Young, M. and Roberts, G. (1994). Air pollution effects on hospital admissions: a statistical analysis of parallel time series. Environmental and Ecological Statistics 1, 325-332.
Burnett, R.T., Dales, R.E., Raizenne, M.E., Krewski, D., Summers, P.W., Roberts, G.R., Raad Young, M., Dann, T. and Brooke, J.R. (1994). Effects of low ambient levels of ozone and sulfates on the frequency of respiratory admissions to Ontario hospitals. Environmental Research 65, 172-194.
Burnett, R.T. and Krewski, D. (1994). Air pollution effects on hospital admission rates: a random effects modelling approach. Canadian Journal of Statistics 22, 441-458.
Fung, K.Y., Krewski, D., Rao, J.N.K. and Scott, A.J. (1994). Tests for trend in developmental toxicity experiments with correlated binary data. Risk Analysis 14, 621-630.
Krewski, D., Withey, J.R. Ku, L.F. and Andersen, M.E. (1994). Applications of physiological pharmacokinetic modeling in carcinogenic risk assessment. Environmental Health Perspectives 102 (Suppl. 11), 37-50.
Krewski, D. and Zhu, Y. (1994). Applications of multinomial dose-response models in developmental toxicity risk assessment.Risk Analysis 14, 595-609.
*Krewski, D. and Zhu, Y. (1994). Multinomial dose-response models for risk assessment in developmental toxicity. Risk Analysis 14, 595-609.
Leroux, B.G., Fung, K.Y., Krewski, D. and Prentice, R.L. (1994). The use of historical controls in testing for trend in counts. Statistica Sinica 4, 581-601.
Létourneau, E.G., Krewski, D., Choi, J., Goddard, M.J., McGregor, R.G., Zielinski, J. and Du, J. (1994). A case-control study of lung cancer and residential radon exposure in Winnipeg, Manitoba. American Journal of Epidemiology 140, 310-322.
Siemiatycki, J, Dewar, R., Desy, M., Krewski, D., Franco, E. and Richardson, L. (1994). Are the apparent effects of cigarette smoking on lung cancer and bladder cancer due to uncontrolled confounding by occupational exposures? Epidemiology 5, 57-65.
Slovic, P., Malmfors, T., Krewski, D., Mertz, C.K., Neil, N. and Bartlett, S. (1994). Intuitive toxicology II: expert and lay judgements of chemical risks in Canada. Risk Analysis 15, 661-675.
Zhu, Y., Krewski, D. and Ross, W. (1994). Dose-response models for correlated multinomial data from developmental toxicity studies. Applied Statistics 43, 583-598.
Ghadirian, P., Maisonneuve, P., Perret, C., Kennedy, G., Lacroix, A., Boyle, P. and Krewski, D. (1998). A case-control study of toenail selenium and cancer of the breast, colon, and prostate. International Journal of Epidemiology. Submitted.
Krewski, D. and Bakshi, K.S. (1998). Current issues in toxicological risk assessment. Inhalation Toxicology. Submitted.
Rai, S.N., Matthews, D.E. and Krewski, D. (1998). Mixed scale models for survival/sacrifice experiments.Canadian Journal of Statistics. Submitted.
Wang, Q., Leroux, B.G. and Krewski, D. (1998). Trend tests for overdispersed count data with historical controls. Journal of Epidemiology and Biostatistics. Submitted.
(PDF = Postdoctoral fellow; IP = in progress)
| Name | Years | Degree | Title | Present Position |
|---|---|---|---|---|
| Dr. Y. Zhu | 2 | Developmental toxicity | University of South Florida | |
| Dr. J. Denes | 2 | Cancer modelling | Consultant | |
| Dr. Y. Wong | 2 | Pharmacokinetics | McMaster University | |
| Dr. Q. Wong | 4 | PhD | Ames Assay | Memorial University |
| Dr. J. Hu | 1 | Disease surveillance | Harvard University | |
| Dr. R. Rai | 2 | Uncertainty analysis | Health Canada | |
| Dr. S. Cakmak | 2 | Time series analysis | Health Canada | |
| Dr. F. Mo | 2 | Epidemiology | Health Canada | |
| Dr. M. Fyfe | 1 | MD | Community Medicine | University of Calgary |
| Dr. V. Catalin | 3 | PhD | Case-control studies | McGill University |
| Ms. R. Mallick | 2 | PhD (IP) | Epidemiologic methods | Carleton University |
| Mr. M. Raizenne | 2 | PhD (IP) | Respiratory health | Harvard University |
| Ms. A. Willis | 1 | MSc (IP) | Epidemiology | University of Ottawa |